University of Basrah discusses new isotopes of nucleosides

NS5B

A scientific seminar held by College of Pharmacy at the University of Basrah discussed the creating and designing of a new isotope of nucleosides as potential anti-Viral hepatitis type C.

The researcher Bader Saleh has mentioned that despite the development in the treatment of patients with Viral hepatitis C, but it is still an important cause of liver diseases because of its silent nature and the search for an inclusive treatment for the disease by itself is considered as a challenge as for the existence of seven genotypes of the virus and many other sub-types of which may lead to multiple treatments in order to treat the disease. The discovery of several points to disrupt the life cycle of the virus and to stop producing the viral proteins has contributed to the discovery of effective treatments against the virus.

Its worthy to be mentioned the determination of the crystalline structure of the virus (NS5B). This is because it is considered to be the machine for the production of viral DNA. This viral protein has been chosen as an objective for designing and developing an antiretroviral drugs because it is not extant in humans as well as, because the effective position in this protein is preserved in different genotypes of viral hepatitis C. In this research, 2-C- acetyl uridine and (2-1)-C- hydroxyethyl uridine were manufactured. These compounds are expected to give vital anti-Viral hepatitis C and it may be developed in as drugs in the future.

 

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