The department of biology at the collage of science, university of Basra organized a panel discussion entitled (Resistance of new generation of macrolide antibiotic by S.aureus) by the master student Haider Abdulameer Ali
The aim of the study is to determine the prevalence and association of macrolide antibiotics among S. aureus isolated from patients and the development of resistance genes in the bacteria
Macrolides are a group of protein synthesis inhibitors, with broad spectrum activity against both Gram-positive and Gram-negative bacterial strains. It is bactericidal that inhibit bacterial protein synthesis.
The Macrolides (erythromycin, clarithromycin, azithromycin), lincosamides (clindamycin) and streptogramins B (quinupristin). Macrolid antibiotics are structurally unrelated but have a same mechanism of action.
The mechanisms of resistance of MLSB antibiotics in S.aureus occur via modification of the ribosome target which encoded by (erm) gene, efflux pump which encodes (msrA) gene, enzymatic inactivation of the antimicrobial agent and Spontaneous mutation in the 23S rRNA.
S.aureus infections are considered a common cause of both health care associated infections and community acquired infections
The study dealt with the role of antibiotics in fighting the causative bacteria in addition to important factors of virulence possessed by the causative bacteria, include adhesions, clumping factors, fibrinogen-binding, fibronectin-binding proteins, capsule, catalase, coagulase , protein A, hemolysins and enterotoxins.
S. aureus infections can be classified into superficial skin and soft tissue infections (SSTIs), systemic infections and toxinoses
S. aureus can cause diseases like Abscess, Conjunctivitis, Corneal ulcer, Septicemia, Endocarditis, Pneumonia, Toxic Shock Syndrome (TSS), Septic arthritis, Meningitis and Osteomyelitis.
