The College of Education for Pure Sciences in the Department of Chemistry discussed a master’s thesis on (preparation and diagnosis of chalcone compounds and their pyrazole derivatives and study of their biological activities)
The message submitted by the researcher (Haider Hossam El-Din Ramadan) included:
Preparation of six different types of new heterocyclic compounds, where compounds (2N, 4N, 6N, 1S, 6H) were prepared, and these compounds were characterized by FT-IR, proton nuclear magnetic resonance (H-NMR) spectra, and mass spectrometry. Electron sputter ionization (ESI), which confirmed the validity of these structures for heterocyclic compounds. The biological effectiveness of the prepared compounds was studied for two types of bacteria that are pathogenic to humans, which are faecal coliform bacteria, Escherichia coli.
Gram-negative bacteria, and the second type is bacteria that cause infections
Staphylococcus aureus
Positive for Gram stain. The compound that gave the highest effectiveness was compound 6H against both types of pathogenic bacteria under test, followed by compound 2N, then compound 6N, and compound 4N. After that, the biological effectiveness of compound (4N) was studied and its biological effectiveness was studied as an inhibitor of the cholinesterase enzyme in blood serum.
