A master’s thesis at the College of Education for Pure Sciences at the University of Basra discussed the preparation and study of the physical properties of some Schiff bases derived from sulfa drugs and their implicit complexes.
The study presented by a master's student (Nour Ali Abdul-Razzaq) included the preparation of Schiff bases derived from sulfa drugs and its implicit complexes with beta-cyclodextrin and diagnosed by spectroscopic methods. The effect of interference on the physical properties was studied using X-ray diffraction technique and scanning electron microscope, and the particle size distribution was calculated. He also studied the effect of the formation of complexes on the solubility of Schiff bases on their solubility in water by the solubility phase method and by following the method of Higuchi and Connors, and the values of the stability constants of the complexes were calculated. The biological activity was also studied and the complexes were more effective compared to the bases derived from them.
The study aims to study the effect of phase-solubility and compare the physical properties of the implicit complexes with pure medicines to know the effect of the formation of complexes on the solubility of these medicines, which is known as their low solubility in water. Study of the biological activity of the prepared compounds and their underlying complexes as anti-bacterials using two types of bacteria (Staphylococcus Aureus and Escherichia coli) and Candida albicans.
The study concluded that it is easy to prepare the bases of lipids derived from sulfa drugs with implicit complexes (beta-cyclodextrin) by freezing lyophilization using ionic water and they form stable complexes. The spectroscopic techniques used confirm the occurrence of interference between the prepared bases and beta-cyclodextrin, some of them showed partial overlap and some were total overlap. The study showed that the X-ray spectra of the powder for the bases and the implicit complexes derived from it that the crystallographic properties of the bases are higher than the crystalline characteristics of the implicit complexes. The solubility of Schiff bases in non-ionic water improves when forming sub-complexes with (beta-cyclodextrin), which confirms that the complex formed is in a ratio of 1:1. SEM images confirm the difference between the base shapes from their implicit complexes, as well as the rate of volume distribution and average diameter, and this proves if the interference is total or partial. It was found that the implicit complexes are more biologically active compared to the bases derived from them
