in the College of Pharmacy, University of Basrah a Thesis discussed the semi-chronic effects of mefenamic acid and diclofenac sodium on the female reproductive system in rats) by Bodour Abbas Salem The thesis dealt with the study of the semi-chronic effects of low and high drug doses of mefenamic acid and diclofenac sodium on the female reproductive system in rats. The thesis FSH , LH , included a study of the effect of mefenamic acid Diclofenac on ,estrogen . E2 progesterone, prolactin, and prostaglandin levels and glutathione . As well as the study of . histological changes in the ovaries The letter concluded that giving mefenamic acid Diclofenac at low or high pharmacological ,doses has a negative effect on the female reproductive system in rats as evidenced by hormonal .biochemical and histological changes, particularly when a combination of NSAIDs is used
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