The College of Science at the University of Basrah organized a seminar entitled Evaluation of immunosuppressive effect for endophytic fungal products isolated from some plants in Basrah by the graduate student Maha Hani Tawfeeq. The study aims are production of immunosuppressive agents from endophytic fungi isolated from some local plants in Basrah and included isolation and identification endophytic fungi and study chemical properties of their secondary metabolites and study its inhibitory effects against microorganisms and it had anti-microbial activity, also obtained pure xanthones compounds and silver nanoparticles (AgNPs) and study their red blood cell toxicity effects. They were not toxic to red blood cells. The compounds and AgNPs show antioxidant activity, and study their inhibitory activity against immune cells and interleukin 6 (IL6) production. The compounds and AgNPs showed high effectiveness by inhibiting the growth of immune cells and the production of IL6, which they are used in treatment of autoimmune diseases as well as in preventing the rejection of organs transplant, and the study was recommended that increasing interest in secondary metabolites of local endophytes, studying other chemical groups that have an inhibitory effect on the immune system, and increasing interest in silver nanoparticles produced from endophytes, due to their high ability to inhibit immune cells and IL6 production.
