The Pharmacology and Toxicology Department at the College of Pharmacy at the University of Basrah held a seminar entitled (A new drug in the treatment of psychological disorders (schizophrenia)/a new drug used in scientific research)
The discussion panel included a lecture delivered by Dr. Asmaa Muhammad Hussein, in which she stated that
Schizophrenia is a mental illness that can affect thoughts, feelings, and behavior. Symptoms are mainly divided into three categories. They include positive symptoms, which are psychosis, such as hallucinations, delusions, unusual thinking, and disturbed speech. Negative symptoms, which are decreased motivation, planning, and feelings of pleasure, in addition to superficial affect and symptoms. Cognitive problems are problems with attention, concentration, and memory (A412997)
It is considered a new substance in scientific research that works specifically on dopamine D4 receptors and causes a concentration-dependent decrease in the release of electrically stimulated dopamine in the brain.
This dopamine decrease was abolished in animals treated with phencyclidine, in a model of schizophrenia. (schizophrenia) These changes in dopamine D4 receptor function in this animal model of schizophrenia indicate a role for these receptors in schizophrenia itself.
Therefore, by measuring the concentration of dopamine secretion from the brain cells of a laboratory animal model of schizophrenia, injected with the drug phencyclidine and then treated with the drug A412997, which affected dopamine secretion and had an important and special role on dopamine D4R receptors, which suggests the role of this drug in treating schizophrenia with the least possible side effects. It may improve cognitive symptoms in patients.
