a master’s thesis at the College of Pharmacy at the University of Basrah discussed (preparation and diagnosis of the biological activity of some isoxazolidine derivatives)
The researcher Wijdan Abbas Naimah’s dissertation included the preparation of the 1,3-dipolar cycloaddition of nitron with N-phenylmaleimide to prepare eight derivatives of isoxazolidine. These compounds were diagnosed using infrared spectroscopy and NMR spectroscopy of the proton and the thirteenth carbon, in addition to mass spectrometry, and the resonance spectra showed The magnetic nuclear of the isoxazolidines has a double signal in the range (4.94-5.48) that belongs to the H-6a proton with a coupling constant of 7.33 Hz - 9.23 Hz.
The carbon isotope resonance spectra of all isoxazolidine compounds showed three new chemical signals in the aliphatic region, indicating the occurrence of an addition reaction between maleimide and nitron.
The study aimed to evaluate laboratory-prepared compounds to determine their anti-tumor activity against the human cell line MCF_7 using MTT analysis.
The results showed that the compounds (IZ4.IZ7.IZ8) have biological activity against cancer cells with an IC50 rate of (23, 32, 43.5) micrograms/ml..jpeg)
