The study was introduced by MSc student Lamia Hamid Saleh. The thesis dealt with preparing and formulating a drug delivery system designed to treat H.pylori infection affecting the digestive system by using levofloxacin as a drug model. This drug is released in a prolonged manner in order to prolong the time of contact with the bacteria to obtain the best eradication using the effervescent method. The thesis included the development of the polymeric matrix of chitosan and its derivatives, thus chitosan was modified by bonding with glutaraldehyde, covalent bonding with formalin, esterification with glycine and cysteine. Also, a polymeric precursor drug was synthesized from ketosan-levofloxacin ester. These derivatives were spectrophotometrically and thermally diagnosed and evaluated for their anti-bacterial efficacy. The thesis concluded that the esterification of chitosan with cysteine and levofloxacin improved the buoyancy of the drug system, which is a beneficial feature of the gastrointestinal systems, while chitosan combination showed that Levofloxacin significantly improved both swelling and delayed drug release, being considered the ideal formulation for highest swelling and prolongation of stay in acidic environments.
