The College of Science at the University of Basrah organized a seminar entitled (Immunological Microenvironment During Endometrial Carcinoma) by the graduate student Zainab Waleed Abdulkhaleeq Alameer.
The study aims to investigate the immunomodulatory characteristics of the tumor microenvironment in endometrial cancer (EC) by evaluating NK cell inhibitory immune receptors and their ligands in EC tissues compared with non-malignant endometrial tissues. And included detecting the expression levels of NK cell–related markers CD16 and CD56 using immunohistochemistry (IHC), evaluating the expression of the inhibitory receptor CD94/NKG2A and its non-classical MHC class I ligand HLA-E, and determining the expression of inhibitory KIR-related receptors (CD158) and their ligand HLA-C. And the study recommended conducting future studies with larger sample sizes to validate the findings, incorporating functional assays to evaluate NK cell cytotoxic activity, and further investigating immune checkpoint pathways, particularly the CD94/NKG2A–HLA-E and KIR–HLA-C axes, as potential therapeutic targets in endometrial cancer.
