Master's thesis at the University of Basra examines the extraction and isolation of pyrolizidine alkaloids
A master's thesis at the College of Pharmacy, University of Basra, examined the extraction and isolation of pyrrolizidine alkaloids from certain species of the Boraginaceae family in Iraq and assessed their biological activity.
The thesis, submitted by student Nardin Sarmad Abdul Razzaq, aimed to extract and isolate pyrrolizidine alkaloids (PAs) from two species of Heliotropium, identify and diagnose them using HPLC and GC-MS techniques, and confirm their identity by comparison with reference standards.
The thesis included a study that involved collecting and analyzing two species of Heliotropium, namely H. crispum and the newly registered species H. curassavicum from southern Iraq, where heliotropine was extracted and isolated from both species and the antioxidant and anticancer activities of both plant extracts and heliotropine compound were evaluated on human breast cancer cells (MCF-7), In addition, the role of reactive oxygen species (ROS) in stimulating programmed cell death (apoptosis) in MCF-7 cells was studied.
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