Doctoral Dissertation at the University of Basrah Explores the Evaluation of Apple Seed Emulsion on Normal and Cancer Cell Lines
A doctoral dissertation at the College of Veterinary Medicine, University of Basrah, examined the effects of an emulsion derived from apple seed oil extract on the normal Vero Salm cell line and the A431 cancer cell line associated with skin cancer.
The dissertation, presented by PhD candidate Ruqayya Kadhem Jawad, aimed to evaluate the effectiveness of the nano-emulsified apple seed oil on cell lines through both in vitro and in vivo experiments, including the induction of dermatitis and observation of pathological changes in the aforementioned major organs.
The study involved chemically inducing dermatitis in adult male rats, followed by testing the nano-emulsion of apple seed oil using two treatment approaches: topical application and intraperitoneal injection. It then tracked the emulsion’s effects on the histological changes caused by the chemical agent, as well as conducted tests to detect immune-specific protein markers.
The dissertation concluded that the emulsion exhibited cytotoxic activity against the skin cancer cell line, reduced chronic inflammation, and gradually restored tissue morphology to its normal state. It also decreased protein expression associated with immune response in tissue samples.
Department of Media and Governmental Communication
