University of Basrah Discusses a Molecular Immunological Study of Tumor Necrosis Factor-Alpha and Its Association with MMP-2 and CCL4 in Cataract Patients
A master’s thesis at the College of Medicine, University of Basrah examined a molecular immunological study of tumor necrosis factor-alpha (TNF-α) and its association with MMP-2 and CCL4 in cataract patients from Dhi Qar, southern Iraq.
The thesis, presented by Noor Al-Din Ali Hatem Taher, aimed to identify potential biomarkers and genetic factors that may contribute to improving disease diagnosis and the development of treatment options.
The study concluded that elevated TNF-α levels may contribute to regulating MMP-2 and CCL4 concentrations. Although genetic variations in TNF-α do not appear to have a direct effect on cataract progression, the findings suggest that inflammatory processes mediated by TNF-α could influence the expression or biological activity of both MMP-2 and CCL4. This highlights the importance of systemic inflammation in cataract development, independent of TNF-α genetic variations, and underscores the need for further research to better understand these mechanistic relationships.
Department of Media and Governmental Communication
