Master’s Thesis at the University of Basrah Explores Baclofen Delivery via Microneedles
A master’s thesis at the College of Pharmacy, University of Basrah, investigated the transdermal delivery of baclofen using microneedles.
The thesis, submitted by graduate student Aya Khalid Jameel, aimed to examine the feasibility of transporting baclofen through the skin by means of microneedles, which create micro-sized pores in the stratum corneum—the primary barrier to transdermal permeation. The process was monitored over a period of 72 hours, offering a potential improvement in patient adherence to therapy and reducing certain side effects that may occur with oral administration of the drug.
The study involved the fabrication of hydrogel-based microneedles loaded with baclofen through a casting technique that incorporated polymers in specific ratios. The hydrogel microneedle arrays were then subjected to a series of characterization tests to identify the optimal formulation.
Findings demonstrated the stability of the stored samples under defined conditions, as well as the homogeneity of baclofen with the employed polymers, with no evidence of chemical interactions between them.
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