Master's thesis at University of Basrah examines the role of aryl hydrocarbon receptor in asthma
A master's thesis at College of Science at University of Basrah examined the role of aryl hydrocarbon receptor in asthma patients in Basrah city.
The thesis of the student Alia Abboud Mahdi aims to estimate blood parameters in asthma patients and determine serum levels of IgE, IL-4, IL-17 and AhR in patients and healthy people.
The thesis included identifying the evaluation of the role of AhR in the pathophysiology during asthma.
It was concluded that the increased level of IgE is significantly associated with the mechanism of causing asthma, and the level of Ahr was significantly higher in asthma patients, which revealed the essential role of Ahr in causing chronic inflammation and as an immunomodulator. IL-17 and Ahr play an important role in the pathogenesis of asthma and its phenotype (non-type 2 asthma), while no clear effect of IL-4 was documented in this study. The positive association between the study variables confirms their role in causing asthma, and estimating the level of IL-17 is an excellent parameter to identify asthma patients, especially those with non-type 2 asthma. Also, estimating the level of Ahr is a good parameter to identify asthma patients, especially those with non-type 2 asthma.
She recommended conducting a molecular experiment using qRT-PCR or SNP variation of the Ahr gene in asthma and its relationship to asthma phenotypes, and conducting a similar study that includes more cytokines such as IL-31 and IL- 33 to investigate the relationship between them and Ahr during asthma.
Government Media and Communication Department
