Master's thesis at University of Basrah investigates the gastroprotective effect of the fruit and seed extract of Iraqi palm dates
A master's thesis at College of Pharmacy at University of Basrah investigated the gastroprotective effect of the fruit and seed extract and a combination of the fruit and seed extract together from Iraqi palm dates on gastric ulcers induced by ethanol in rats.
The thesis submitted by the student Mustafa Kazem Hussein aims to study the gastroprotective benefits of Iraqi date palm (Phoenix dactylifera L. Cv. " Barhi) against ethanol-induced gastric ulcer models in rats.
The results showed that the total phenolics in date fruit and date seeds were 7.25 equiv (calcium phosphate / 100 g) and 1.88 equiv (calcium phosphate / 100 g), respectively, while the total flavonoids in date fruit and date seeds were 3.5 equiv (quercetin / 100 g) and 1.4 equiv (quercetin / 100 g), respectively.
Ethanol produced gastric ulcers by increasing the gastric volume content and hydrochloric acid concentration in rats. In addition, the gastrin and hydrochloric acid content in blood increased significantly after ethanol treatment. On the other hand, ethanol significantly reduced antioxidant activity when measured at concentrations Glutathione in serum and gastric tissue. Furthermore, the intestinal mucosa of animals was significantly affected by ethanol, as evidenced by swelling, erosion, and redness of the mucosal tissue surface and perforation, resulting in flaky linear bleeding.
A decrease in gastric volume and hydrochloric acid content was observed in rats given the fruit extract alone or the seed and fruit extract together, with a significant decrease in gastrin concentration and increased glutathione concentrations in serum and gastric tissue in rats treated with Iraqi Barhi date extract.
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