Master's Thesis at University of Basrah Explores Curcumin Derivatives
A master's thesis at the College of Pharmacy, University of Basrah, examined "Preparation of Heterocyclic Derivatives of Curcumin-Like Compounds with Potential Biological Activity: A Molecular Docking Study."
The thesis, presented by student Ola Abdul Hussein Ouda, aimed at the chemical synthesis of compounds 1-20, characterizing them, and evaluating their pharmacological efficacy as anti-cancer and anti-inflammatory agents through molecular docking studies.
The study involved preparing novel curcumin derivatives with heterocyclic rings, characterized using modern spectroscopic techniques such as mass spectrometry and nuclear magnetic resonance spectroscopy.
The study concluded that the synthesized compounds exhibited better bioactivity than the original curcumin, which is unstable and less potent compared to the synthesized derivatives.
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